Reducing disturbances during start of production of new products is of high importance to assure that products reach the market on-time with the intended quality and volume. Therefore, identification and elimination of sources of such disturbances is necessary. Since the literature about such disturbances in low-volume manufacturing industries are limited, this paper is aimed to identify the common sources of such disturbances and the possible solutions to mitigate them in low-volume manufacturing industries. A multiple-case study has been conducted to achieve this aim. The results show that main sources of disturbances are lack of opportunities to test and refine products, considering the production system “as is” and putting extensive focus on product functionality rather than its manufacturability. Moreover, using the knowledge and experiences from production of previous similar products is identified as a source of learning and compensation for lack of opportunities for test and refinement.