Many scholars in China have done a lot of research on regionalization of agricultural resources in the Huang-Huai-Hai Plain, but there is no quantitative research on agriculture of the whole plain. By using qualitative and quantitative analysis based on the basic data collected over 300 counties in the Huang-Huai-Hai Plain, considering such indicators as the natural resources of the plains and the yields of major crops and agricultural GDP,this paper designed the agricultural zoning of the plains. The Plain was classified into high-yield areas and low-producing areas. High-yield areas were divided into advantageous regions of foodstuff, advantageous regions of cotton, advantageous regions of oil, advantageous regions of foodstuff and cotton, advantageous regions of foodstuff and oil, advantageous regions of cotton and oil, and advantageous regions of foodstuff, oil and cotton. And these areas have been divided specifically. The research is of referential values for agricultural development of the Huang-Huai-Hai Plain, both practically and theoretically.