This paper analyses the statements of video imaging, CT, infrared thermography and radiography applied in the road nondestructive testing, and design a path planning mobile robot with GPS positioning which can remarkably increase the efficient of road nondestructive testing. Besides, appropriate algorithm for nondestructive testing on the road autonomous mobile robot path planning is given. This method is simplicity, versatility, and efficiency. The mobile robot are selected for example and the simulation results represent the effectiveness of this method.