The orthogonal signal correction of Wold algorithm was introduced in this thesis, which was combined with the partial least square algorithm. Calibration model of five components of benzene, methylbenzene, chlorobenzene, benzaldehyde and acetophenone in the mixed liquid samples were developed and validated by the method of independent . The result indicated that the calibration models of the components of benzene, methylbenzene, chlorobenzene and benzaldehyde will be developed well after the 1-dimension OSC filter; while a good calibration model of the component of acetophenone will be acquired after the 2-dimension OSC filter.