Suitability evaluation of soil for tobacco is the base of spatial analysis and optimization disposition. It provides scientific basis for reasonable development of soil for tobacco. Taking soil in San Menxia city of Henan province as a study of object, five factors which had relation of tobacco growth are adopted, grey cluster method are carried out to appraise suitability evaluation. The result shows that some soil area of Lingbao, Mianchixian and Shanxian are higher suitability areas that contain higher organic matter and K contents ,while the soil area of Lushixian has lower organic matter and N contents are less suitability area. Compared with traditional methods, grey cluster method determined the weight based on factors. The result is objective reasonably.