The paper addresses specific issues of the local governance in its transition to the knowledge society and the web based processes. The innovative e-Governance approach creates a new regional framework for changing the process of the sustainable strategy design and implementation, from a system-oriented to an actor-driven one, focusing on the development of two ways online channels for supporting the pro-active citizens' behavior and their involvement in the consultation and decisional processes. The solution, based on web 2.0 technologies, integrates e-Knowledge, e-Consultation and e-Voting tools in a regional portal, facilitating the bottom-up decision-making processes. The regional virtual portal provides simultaneously a quantitative approach represented by the information concerning the regional opportunities and possible evolution trends, based on advanced modeling tools and set of indicators, and, complementary, a qualitative approach using various tools for the direct expression of the specific actors' opinions, creating a holistic image on the regional development.