Assessing the digital readiness of companies is becoming crucial to undertake a successful journey towards the digitalization of industry. Recently, the attention of both scholars and practitioners has turned to an extension of the assessment to the whole Supply Chain (SC). Given the importance of reaching a high level of integration and digital readiness in all the various actors that collaborate in the SC, some Digital Supply Chain (DSC) assessment models have been proposed mainly in the consulting field. However, to fully exploit the benefits of measuring the digital readiness of a SC, companies need also to be supported in the identification and prioritization of the most relevant opportunities triggered by the deployment of DSC projects. To this purpose, this paper presents a framework that links the potentials of DSC implementations with the SC operation processes, highlighting the most suitable technologies to deploy them. The framework has been conceived starting from a literature review and aims at providing a valuable tool to all the stakeholders involved in the transformation towards Digital Supply Chains.