TRIZ is a well-known innovative problem solving method, massively implemented within big industrial groups to boost their efficiency in innovation process. TRIZ is also a creativity technique providing a wide set of methodological formalized concepts applied through numerous tools. Case studies showed how start-ups can benefit from business innovation methodological good practices by enforcing the link between invention, innovation and intellectual property. This paper aims at demonstrating the ability of the formal TRIZ approach to contribute to the feasibility of the next step: helping entrepreneurs and start-ups’ stakeholders in accelerating their «serial innovation» capability while keeping the control of the Lean process. To achieve this ambitious and crucial objective, the team will share its best practices of TRIZ expertise aiming at fostering the Lean canvas in-depth analysis thanks to the powerful TRIZ appropriate tools in order to dramatically reinforce and secure the pioneer spirit.