Open Innovation is a strategy used by organizations to more promptly comply with the continuous changing market needs and renew their income streams. But its effective achievement depends on the practitioners’ ability to assume concrete mindset, like openness, acceptance of risk, talent to build trust and to learn from successes as well as from failures. Based on these assumptions, the paper explores the concept of mindset in open innovation. The approach is twofold combining sentiment analysis over interviews on web documents with semi-directive interviews conducted in IT companies. The results include a characterization of OI practitioners’ mindset concerning risk and related elements.