Turbulent changes of the production program challenge the suitability of the operating point of the production system. This can result in a lack of efficiency and productivity of a formerly mature configuration of a production system. In this case, the logistic positioning becomes obsolete. Therefore, a periodic monitoring of the system configuration is necessary to ensure a resilient production. To cope with those challenges, this paper introduces an approach which evaluates strategies in terms of adjusting the system configuration. On the one hand, this refers to control strategies influencing the temporal organization and thus the system’s behavior. On the other hand, also a variation of the spatial organization in terms of the layout of the production system can be considered. For different production structures effects of changed production programs on the system configuration and its resilience is explained and adequate measures for adapting the temporal or spatial structure are appraisable.