Laos is a country with abundant natural resources, low labor costs and land rents, which has natural geo-economic relationship with China, and gradually became one of the important destinations of Chinese enterprises’ foreign direct investment. Meanwhile, China has become the largest overseas investment country in Laos. Based on the symbiotic relationship between Laos and China, this paper studies the dynamics of Laos-China cross-border cooperation from three aspects, including Laos’s reform, China’s “One Belt One Road” and “going abroad” strategy, and the multi-agent coordination of external demand respectively. This paper presents the “overseas Jiangsu” mode of Laos-China cross-border collaboration strategy and offers some elicitation to the cross-border cooperation in Laos-China. Finally, this paper proposed to establish the “overseas Jiangsu” mode of Laos-China cross-border collaboration strategy .