This paper defines the Smart x Sensing reference model (S2-RM) as a model that fulfills the requirements, characteristics and processes of a Manufacturing Collaborative Network to face the challenge of a digital economy. All the attributes have been formalized using Unified Modeling Language (UML). The S2-RM allows a complete description using the five generic viewpoints stated in the Reference Model of Open Distributed Processing (RM-OPD): enterprise, information, computation, engineering and technology. A Collaborative Network Organization that produces micro-machines is used as pilot demonstration showing the specific purpose of each viewpoint and its relevance to achieve a smart and sensing environment.