The health status of a person can be assessed by specialized professionals with the help of medical devices. The assessment, in real-time, would be useful as most of the times a person is not in presence of health professionals. But own assessment lacks precision and reaction time that could be risky in critical conditions. The pervasiveness of Internet connections and ubiquity of smart devices makes it possible to overcome that limitation. By using sensing capabilities of portable/wearable devices in conjunction with medical knowledge and clinical history it is possible to monitor a person’s health status in real-time with reaction mechanisms. The objective is to keep track of collected evidence, and relate with existing knowledge for better assessment. This paper proposes a framework, inspired by the brain and physiology, capturing real-time health related information, at a person’s location, submitting that to the cloud for reasoning and decision and triggers advice or request medical assistance.