This paper proposes a methodology of performance sensitivity analysis of reverse supply chain systems by using simulation. This paper discusses two types of reverse logistics model: PUSH-type and PULL-type. And, it proposes a generic method to analyze system performance by using discrete-event simulation and factorial experiment design. The characteristics of reverse supply chain systems (PUSH-type and PULL-type) are shown in detail. The result of these analyses would provide useful data for planning reverse supply chain systems.