Moving from the key features of knowledge economy and taking into consideration the new paradigms emerged in economic and managerial studies, in many countries several institutions have promoted the formation of strategic alliances to stimulate the reindustrialization and promote the national and regional development. The Italian government has recently defined a new legal framework (law n. 122/2010) to implement collaborative strategic networks through the “enterprises’ network agreement”. The latest data about the implementation of the new form of collaborative networks show a rapid spread of the agreement and represent an important result to read in the light of economic, managerial and industrial literature. In the paper the main characteristics of the agreement are described and discussed, and an analysis based on historical data, since two years from its introduction, is presented. The aim is to evaluate how this kind of tool can have an impact on the reindustrialization of the Country and the emergence of second generation VBE on this process.