In this paper, we focus on the One-of-a-Kind Production (OKP) industry, where each product is designed and manufactured based on specific customer requirements to a large extent, according to an Engineer To Order (ETO) approach. This research has been carried out among the “SIGI-X” project, funded by the Italian Ministry of Economic Development (MISE). The paper illustrates an empirical study on the state-of-the-art of information systems supporting the leading processes in OKP companies. Through a set of 21 case studies in Italian companies producing special machines, we aim to: identify and investigate strengths and weaknesses of the main OKP business processes; analyze the ICT support and its level of integration among the different ICT solutions; identify levers for improvement, concerning organizational, methodological and informatics aspects; build a practical framework that could define and link the main processes in order to obtain a sort of guideline useful for re-engineering the processes, and laying the foundation for a new integrated ICT business template for OKP companies. The lack of support of three fundamental tasks such as project management, planning and cost control underlines that there is substantial room for improvement under the ICT support perspective. Finally, the development of an integrated IT environment to support (in particular) project management and planning activities, specifically addressed to OKP context, would help these companies to improve their performance and competitiveness.