In the current dynamic, volatile and competitive playground, the design and managing of global production and logistic networks has become a crucial issue even for SMEs, although with the difficult added that they have limited resources. Thus, how dealing with these complex production networks present a real challenge for this kind of companies. In order to do so, it is necessary to provide business managers a useful guideline to face the internationalization process in an effective way. Therefore, the aim of this paper is to propose a framework, which takes into account the three main problems (new facilities implementation, global supplier network and multi-site network) related to Operations configuration, to aid managers in the different stages of the decision making and propose useful principles, methods and techniques depending on the problem.