In order to help farmers to understand soil nutrients, use effectively our soil and protect our environment, at the same time to improve sustainable development of the agricultural system, the topsoil samples were collected form yushu city .The ways of combining Geostatistics with GIS were applied to analyze the spatial variability of soil nutrients, such as Alkaline hydrolysis nitrogen, available phosphorus and available potassium. All results shows that Alkaline hydrolysis nitrogen, available phosphorus and available potassium in the coefficient of variation were from 9% to 46%, and the largest coefficient of variation of available phosphorus was 46%. By using Semi-variogram function of statistical analysis, Alkaline hydrolysis nitrogen, available phosphorus and available potassium show Moderate spatial dependency. The relevance of space about available phosphorus may be the weakest, which is effected mainly by random factors. So the different management and the level of fertilizer may be done according the spatial variability of different area format.